Figure 1.

Structure of yeast Prp43p. (A) Schematic representation of the domain organization of Prp43p. Structural domain names and boundaries are indicated on top, conserved sequence motifs (roman numerals) and domains (hatched areas) beneath. (B) Stereo view of the overall structure of Prp43p in complex with ADP-Mg²⁺. The six structural domains of Prp43p are coloured as in (A). The β-hairpin element (light blue) protrudes from the RecA2 domain (dark blue) between motifs V and VI. The ADP molecule is shown as magenta sticks, and the magnesium ion is represented as a magenta sphere.