Editing reduces drug affinity of Kv1.1 channels. (A–F) The effects of the drugs (A) S020951, (B) AVE0118, (C) S0100176, (D) Psora-4, (E) 4-aminopyridine and (F) the scorpion toxin rHongotoxin-1 (rHgTX1) on Kv1.1 and Kv1.1I400V channels. Left-hand panels show Kv1.1 or Kv1.1I400V currents activated by voltage steps to +40 mV before and after application of the same concentration of blocker (black, controls; blue, Kv1.1 plus drug; red, Kv1.1I400V channels plus drug). The right-hand panels show the dose–response curves for Kv1.1 (blue) and Kv1.1I400V (red).