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. 2010 Jun 4;29(13):2242–2252. doi: 10.1038/emboj.2010.94

Figure 2.

Figure 2

TLR4 is important for CO-induced skin inflammation. The skin from WT and different KO mice was taken after 12 or 24 h of CO or acetone treatment and analysed for gene expression or production of different cytokines. (A) Real-time PCR analysis of different inflammatory mediators on mRNA isolated from skin extracts after 12 h of CO treatment. The results are expressed as fold induction over acetone-treated skins in each group after normalization to L32 mRNA. (B) Production of inflammatory cytokines IL-6, IL-17 and IL1-β in the skins as measured by ELISA after 24 h of CO or acetone treatment. Values represent means±s.d. of the mean from at least three skin samples from each genotype and each experiment was repeated at least twice. *P<0.05, **P<0.01, NS, not significant.