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. 2010 Jun 1;103(1):36–42. doi: 10.1038/sj.bjc.6605713

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Copyright © 2010 Cancer Research UK

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Effects of YM155 on DNA-damaging agent-induced apoptosis and caspase-3 activity in H460, Calu6, H358, or PC14 cells. Cells were incubated with 50 nM YM155 or vehicle (0.1% dimethyl sulfoxide (DMSO)) for 48 h and then for the indicated times (upper panels) or for 24 h (lower panels) in the additional absence or presence of 10 μM CDDP (A) or CBDCA (B). The percentage of apoptotic cells was then determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining (upper panels), and cell lysates were assayed for caspase-3 activity (lower panels). All data are means±s.e. from three independent experiments; those for caspase-3 activity are expressed relative to the corresponding value for the control condition. ^*P<0.05, ^**P<0.001, ^***P<0.0001 vs the corresponding value for CDDP or CBDCA or for YM155 alone.