Table 2. Age-adjusteda and multivariateb relative risks of colorectal cancer associated with diabetes status according to ethnic or racial group, site and stage of disease in the Multiethnic Cohort.

	European Americans			African Americans			Native Hawaiians			Japanese Americans			Latinos			All
		RR (95% CI)			RR (95% CI)			RR (95% CI)			RR (95% CI)			RR (95% CI)			RR (95% CI)
	Cases	Age-adj	Multi	Cases	Age-adj	Multi	Cases	Age-adj	Multi	Cases	Age-adj	Multi	Cases	Age-adj	Multi	Cases	Age-adj	Multi
All	664	1.26 (0.99–1.59)	1.16 (0.91–1.48)	791	1.16 (0.98–1.37)	1.16 (0.97–1.38)	205	0.91 (0.64–1.29)	0.89 (0.62–1.27)	1197	1.29 (1.12–1.50)	1.27 (1.09–1.47)	692	1.24 (1.05–1.48)	1.21 (1.02–1.46)	3549	1.22 (1.12–1.33)	1.19 (1.09–1.29)
P-value		0.058	0.24		0.084	0.097		0.59	0.52		0.001	0.002		0.013	0.030		<0.001	<0.001
PIntc																	0.43	0.43
Men	359	1.07 (0.77–1.48)	0.96 (0.69–1.35)	323	1.01 (0.77–1.33)	1.02 (0.77–1.34)	117	0.95 (0.60–1.49)	0.97 (0.60–1.55)	712	1.15 (0.95–1.38)	1.15 (0.95–1.39)	410	1.25 (1.00–1.56)	1.31 (1.04–1.64)	1921	1.12 (1.00–1.26)	1.12 (0.99–1.26)
P-value		0.69	0.83		0.93	0.91		0.82	0.90		0.15	0.16		0.048	0.023		0.048	0.063
PIntc																	0.66	0.65
Women	305	1.52 (1.08–2.13)	1.48 (1.03–2.12)	468	1.27 (1.02–1.57)	1.27 (1.02–1.58)	88	0.89 (0.52–1.54)	0.83 (0.47–1.46)	485	1.56 (1.24–1.97)	1.50 (1.18–1.91)	282	1.25 (0.95–1.64)	1.09 (0.82–1.45)	1628	1.34 (1.19–1.52)	1.28 (1.12–1.46)
P-value		0.017	0.033		0.030	0.036		0.69	0.51		<0.001	0.001		0.11	0.54		<0.001	<0.001
PIntc																	0.32	0.32
Colon	501	1.33 (1.02–1.73)	1.20 (0.92–1.59)	642	1.25 (1.04–1.50)	1.24 (1.02–1.49)	144	0.87 (0.57–1.32)	0.84 (0.54–1.30)	847	1.35 (1.14–1.60)	1.34 (1.13–1.60)	494	1.13 (0.91–1.39)	1.10 (0.88–1.36)	2628	1.24 (1.12–1.36)	1.20 (1.09–1.32)
P-value		0.035	0.18		0.018	0.028		0.50	0.43		0.001	0.001		0.26	0.40		<0.001	<0.001
PIntc																	0.30	0.30
Right colon	307	1.40 (1.00–1.95)	1.32 (0.93–1.87)	397	1.18 (0.93–1.49)	1.17 (0.92–1.49)	68	1.06 (0.60–1.88)	1.17 (0.64–2.14)	423	1.47 (1.16–1.86)	1.46 (1.14–1.85)	269	1.08 (0.81–1.43)	1.07 (0.79–1.43)	1464	1.26 (1.11–1.43)	1.23 (1.08–1.41)
P-value		0.050	0.12		0.17	0.21		0.84	0.60		0.0010	0.002		0.61	0.67		<0.001	0.002
PIntc																	0.45	0.47
Left colon	182	1.34 (0.86–2.07)	1.14 (0.72–1.80)	223	1.39 (1.03–1.88)	1.38 (1.01–1.89)	71	0.68 (0.36–1.31)	0.61 (0.31–1.18)	406	1.26 (0.98–1.63)	1.27 (0.98–1.64)	209	1.15 (0.84–1.59)	1.10 (0.79–1.53)	1091	1.23 (1.06–1.43)	1.18 (1.01–1.38)
P-value		0.20	0.58		0.032	0.044		0.25	0.14		0.069	0.077		0.39	0.59		0.008	0.040
PIntc																	0.36	0.34
Rectum	163	1.03 (0.61–1.73)	1.00 (0.59–1.71)	149	0.81 (0.53–1.25)	0.85 (0.54–1.32)	61	1.02 (0.55–1.88)	1.01 (0.53–1.91)	350	1.16 (0.88–1.54)	1.10 (0.83–1.47)	198	1.57 (1.15–2.13)	1.55 (1.13–2.14)	921	1.17 (0.99–1.38)	1.15 (0.96–1.36)
P-value		0.91	1.00		0.34	0.47		0.96	0.99		0.29	0.51		0.004	0.007		0.071	0.12
PIntc																	0.15	0.18
Localised	277	1.39 (0.97–1.97)	1.22 (0.84–1.75)	278	1.31 (1.00–1.72)	1.32 (1.00–1.76)	102	0.97 (0.60–1.57)	0.95 (0.57–1.57)	551	1.33 (1.07–1.65)	1.26 (1.01–1.56)	252	1.18 (0.88–1.57)	1.19 (0.88–1.61)	1460	1.27 (1.11–1.44)	1.21 (1.06–1.39)
P-value		0.070	0.30		0.053	0.052		0.89	0.83		0.009	0.040		0.27	0.25		<0.001	0.005
PIntc																	0.73	0.70
Regional	317	1.15 (0.81–1.63)	1.07 (0.74–1.54)	377	0.95 (0.74–1.23)	0.95 (0.73–1.24)	97	0.92 (0.55–1.51)	0.87 (0.52–1.47)	579	1.25 (1.01–1.54)	1.24 (1.00–1.54)	316	1.39 (1.09–1.78)	1.33 (1.03–1.72)	1686	1.17 (1.03–1.32)	1.14(1.01–1.30)
P-value		0.45	0.72		0.71	0.73		0.73	0.61		0.042	0.052		0.009	0.029		0.013	0.036
PIntc																	0.19	0.21

Abbreviations: BMI=body mass index; CI=confidence interval; NSAIDs=non-steroidal anti-inflammatory drugs; RR=relative risk.

^aAdjusted for sex (except in models for men/women), race (except in models for each ethnic group), and and stratified on age at baseline questionnaire.

^bFurther adjusted for BMI, smoking, NSAIDs use, education, alcohol intake, saturated fat intake, unsaturated fat intake, dietary fibre intake, physical activity, family history of colorectal cancer.

^cP-value for interaction between ethnic group and diabetes.