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. Author manuscript; available in PMC: 2010 Jul 16.
Published in final edited form as: Biochemistry. 2002 Mar 26;41(12):3991–4001. doi: 10.1021/bi011922x

Figure 1.

Figure 1

Sequence of PrP and the octarepeat domain. (a) This sequence representation of PrPC locates the globular C-terminal domain, the glycosylphosphatidylinositol (GPI) membrane anchor, and the octarepeat domain. Also shown is a flexible region implicated in multimerization that accompanies PrPC → PrPSc conversion. Cu2+ binding within the octarepeats involves the specific residues HGGGW (underlined). (b) Alignment of the octarepeat domain from several species. Note that the only sequence variation within the HGGGW segments is either variation of the third glycine (to serine in two mouse octarepeats) or insertion of an additional glycine (in the porcine sequence).