Table 1.
Functional analysis of genes differentially expressed in ovaries during 24 hr fadrozole exposure
| ENRICHED GO TERMS UP-REGULATED FOR FAD IN VITRO | ENRICHED GO TERMS UP-REGULATED FOR FAD IN VIVO | ||
|---|---|---|---|
| GO Name | p Value | GO Name | p Value |
| morphogenesis of an epithelium | 0.011 | pregnancy | 0.009 |
| protein amino acid glycosylation | 0.029 | ossification | 0.012 |
| glycoprotein biosynthesis | 0.033 | regulation of cell growth | 0.012 |
| biopolymer glycosylation | 0.034 | amino acid derivative catabolism | 0.020 |
| embryonic development (sensu Metazoa) | 0.046 | tissue development | 0.021 |
| glycoprotein metabolism | 0.046 | anti-apoptosis | 0.027 |
| cell differentiation | 0.029 | ||
| osteoblast differentiation | 0.031 | ||
| development | 0.036 | ||
| oogenesis | 0.042 | ||
| reproductive physiological process | 0.043 | ||
| nucleoside triphosphate metabolism | 0.044 | ||
| ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VITRO | ENRICHED GO TERMS DOWN-REGULATED FOR FAD IN VIVO | ||
| GO Name | p Value | GO Name | p Value |
| gastrulation | 0.008 | negative regulation of apoptosis | 0.002 |
| DNA replication | 0.009 | anti-apoptosis | 0.003 |
| cellular carbohydrate metabolism | 0.016 | negative regulation of programmed cell death | 0.003 |
| carbohydrate metabolism | 0.019 | purine ribonucleotide biosynthesis | 0.004 |
| potassium ion transport | 0.021 | pregnancy | 0.006 |
| macromolecule biosynthesis | 0.023 | nucleoside triphosphate metabolism | 0.007 |
| glucose catabolism | 0.025 | transcription from RNA polymerase II promoter | 0.009 |
| hexose catabolism | 0.026 | regulation of physiological process | 0.012 |
| monosaccharide catabolism | 0.026 | signal transduction | 0.013 |
| positive regulation of cellular process | 0.026 | purine nucleoside triphosphate biosynthesis | 0.015 |
| alcohol catabolism | 0.027 | nucleoside triphosphate biosynthesis | 0.016 |
| physiological process | 0.028 | G-protein signaling, coupled to cyclic nucleotide second messenger | 0.020 |
| energy derivation by oxidation of organic compounds | 0.032 | reproductive organismal physiological process | 0.021 |
| mitochondrial transport | 0.033 | nucleoside metabolism | 0.024 |
| positive regulation of biological process | 0.035 | reproductive physiological process | 0.024 |
| glucose metabolism | 0.036 | energy coupled proton transport, down electrochemical gradient | 0.024 |
| protein amino acid glycosylation | 0.040 | ATP synthesis coupled proton transport | 0.024 |
| muscle contraction | 0.042 | regulation of cellular physiological process | 0.026 |
| protein biosynthesis | 0.043 | cell-cell adhesion | 0.027 |
| glycoprotein biosynthesis | 0.044 | cell proliferation | 0.031 |
| carbohydrate catabolism | 0.044 | regulation of programmed cell death | 0.038 |
| cellular carbohydrate catabolism | 0.044 | apoptosis | 0.038 |
| biopolymer glycosylation | 0.045 | G-protein signaling, coupled to cAMP nucleotide second messenger | 0.038 |
| cellular process | 0.046 | development | 0.040 |
**The full list of significant GO terms are in Additional File 1.