Table 1.
Characteristics of patients aged 35-74 years free of CKD at baseline in the QResearch derivation and the THIN validation cohort.
|
QResearch derivation cohort (n = 1,574,749) |
THIN Validation cohort (n = 1,581,745) |
|
|---|---|---|
| Women | 775,091 (49.22) | 784005 (49.57) |
| Mean age(SD) | 47.3 (11.1) | 49 (11.1) |
| Mean Townsend deprivation score (SD) | -0.5 (3.4) | -0.7 (3.1) |
| Ethnic group | ||
| white/not recorded | 1,511,028 (95.95) | 1,548,749 (97.91) |
| Indian | 12,360 (0.78) | 8,313 (0.53) |
| Pakistani | 6,582 (0.42) | 2,370 (0.15) |
| Bangladeshi | 2,671 (0.17) | 797 (0.05) |
| Other Asian | 5,239 (0.33) | 3,652 (0.23) |
| Black Caribbean | 9,596 (0.61) | 4,131 (0.26) |
| Black African | 10,535 (0.67) | 5,224 (0.33) |
| Chinese | 2,819 (0.18) | 1,279 (0.08) |
| Other | 13,919 (0.88) | 7,230 (0.46) |
| Smoking status | ||
| non smoker | 804,831 (51.11) | 641,929 (40.58) |
| ex smoker | 286,731 (18.21) | 236,820 (14.97) |
| light smoker | 101,273 (6.43) | 96,347 (6.09) |
| moderate smoker | 124,246 (7.89) | 153,262 (9.69) |
| heavy smoker | 100,891 (6.41) | 150,036 (9.49) |
| smoker amount not recorded | 42,309 (2.69) | 204,564 (12.93) |
| smoking not recorded | 114,468 (7.27) | 98,787 (6.25) |
| Clinical conditions | ||
| Type 1 diabetes | 4,441 (0.28) | 4,940 (0.31) |
| Type 2 diabetes | 49,179 (3.12) | 49,877 (3.15) |
| Cardiovascular disease | 70,865 (4.50) | 80,977 (5.12) |
| Congestive cardiac failure | 7,366 (0.47) | 8,073 (0.51) |
| Peripheral vascular disease | 16,015 (1.02) | 20,066 (1.27) |
| Treated hypertension | 156,506 (9.94) | 142,192 (8.99) |
| Rheumatoid arthritis | 11,933 (0.76) | 14,137 (0.89) |
| Systemic lupus erythematosis | 1,094 (0.07) | 1,103 (0.07) |
| Kidney Stones | 10,674 (0.68) | 12,115 (0.77) |
| Current use of NSAIDS | 425,775 (27.04) | 387,087 (24.47) |
| Family history of kidney disease | 719 (0.05) | 1,097 (0.07) |
| Clinical values | ||
| systolic blood pressure recorded | 1,415,467 (89.89) | 1,437,893 (90.91) |
| mean systolic blood pressure (SD) | 133.1 (19.5) | 133.6 (19.6) |
| body mass index recorded | 1,241,158 (78.82) | 1,253,686 (79.26) |
| mean body mass index (SD) | 26.7 (4.7) | 26.8 (4.7) |
| creatinine recorded ever | 880,627 (55.92) | 863,948 (54.62) |
| mean Creatinine (SD) | 86.2 (15.9) | 86.3 (16.3) |
| creatinine recorded prior to baseline | 331,018 (21.02) | 217,814 (13.77) |
| complete data (for SBP, BMI & smoking) | 1,214,906 (77.15) | 1,226,974 (77.57) |
Values are numbers (%).
Data for the QResearch validation cohort is not shown but is available from the authors.