Table 3.

Morphine equivalent daily dose by time in subjects with intermittent exposure

Years	Number of subjects	Mean ± SD	Median	Min	Max	P25	P75	P95
Half year	48367	62.48 ± 76.43	50.00	0.25	2700.00	37.50	69.17	112.50
> 6 months to 1 year	22494	57.61 ± 85.68	45.00	0.33	6666.67	31.50	65.16	112.50
> 1 to 1.5 years	19130	56.07 ± 69.1	45.00	0.50	2250.00	30.00	64.11	112.50
> 1.5 to 2 years	15553	56.97 ± 73.8	45.00	0.50	2025.00	30.00	65.00	112.50
> 2 to 2.5 years	11588	58.45 ± 69.05	46.15	0.67	1920.00	30.00	67.50	113.44
> 2.5 to 3 years	8119	60.73 ± 82.99	46.88	0.67	1920.00	30.94	67.50	120.00
> 3 to 3. 5 years	5824	58.23 ± 81.27	45.00	1.56	2660.63	30.00	64.29	112.50
> 3. 5 to 4 years	4677	55.71 ± 75.7	45.00	2.50	1808.04	30.00	60.00	112.50
> 4 to 4.5 years	4619	58.57 ± 87.44	45.00	2.50	2025.00	30.00	60.00	120.00
> 4.5 to 5 years	4111	59.42 ± 100.09	45.00	2.50	2700.00	30.00	60.00	112.50
> 5 to 5.5 years	3418	58.56 ± 96.34	45.00	2.50	3535.12	30.00	60.00	120.00
> 5.5 to 6 years	3301	62.96 ± 113.2	45.00	2.50	2890.19	30.00	61.25	120.00
> 6 to 6.5 years	3225	61.66 ± 109.87	45.00	2.45	3368.28	30.00	62.00	120.00
> 6.5 to 7 years	3031	61.81 ± 101.48	45.00	2.50	2239.86	30.00	60.99	114.28
> 7 to 7.5 years	1837	64.44 ± 116.78	45.00	3.75	2695.92	30.00	60.00	128.57
> 7.5 to 8 years	714	62.71 ± 103.76	45.00	4.17	1350.00	30.00	56.25	146.93
> 8 years	179	72.52 ± 124.42	46.32	6.94	937.50	28.75	60.00	300.00

SD, standard deviation; P25, 25^th percentile; P75; 75^th percentile; P95; 95^th percentile