Table 5.

Morphine equivalent daily dose by time in subjects with continuous exposure with cancer diagnosis

Years	Number of subjects	Mean ± SD	Median	Min	Max	P25	P75	P95
Half year	177	65.29 ± 67.61	50.00	7.50	699.57	33.88	77.73	140.63
> 6 months to 1 year	148	86.63 ± 156.56	55.44	7.50	1702.50	30.00	89.10	240.00
> 1 to 1.5 years	79	71.96 ± 86.73	51.46	10.56	560.00	26.25	79.29	294.49
> 1.5 to 2 years	39	90.96 ± 92.61	60.00	15.00	431.88	30.00	98.12	347.94
> 2 to 2.5 years	19	99.55 ± 87.31	75.00	15.00	300.00	37.50	120.00	300.00
> 2.5 to 3 years	9	116.79 ± 95.72	105.00	15.00	318.12	45.00	139.74	318.12
> 3 to 3. 5 years	5	121.9 ± 130.19	45.00	15.00	298.74	27.50	223.27	298.74
> 3. 5 to 4 years	5	115.78 ± 125.49	45.00	15.00	295.71	23.82	199.38	295.71
> 4 to 4.5 years	5	151.37 ± 182.88	45.00	15.00	436.67	26.25	233.96	436.67
> 4.5 to 5 years	4	304.47 ± 422.07	141.43	15.00	920.00	30.00	578.93	920.00
> 5 to 5.5 years	3	394.28 ± 457.61	240.00	33.75	909.09	33.75	909.09	909.09
> 5.5 to 6 years	3	400.01 ± 471.87	233.78	33.75	932.50	33.75	932.50	932.50
> 6 to 6.5 years	3	315.39 ± 321.23	240.00	38.57	667.61	38.57	667.61	667.61
> 6.5 to 7 years	2	187.59 ± 209.35	187.59	39.55	335.62	39.55	335.62	335.62
> 7 to 7.5 years	1	381.73 ± .	381.73	381.73	381.73	381.73	381.73	381.73
> 7.5 to 8 years	0	-	-	-	-	-	-	-
> 8 years	0	-	-	-	-	-	-	-

SD, standard deviation; P25, 25^th percentile; P75; 75^th percentile; P95; 95^th percentile