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. 2010 Jul 16;5(7):e11619. doi: 10.1371/journal.pone.0011619

Figure 8. Potential placement of dSno in the Wingless pathway.

Figure 8

A model depicting the Wg signal transduction pathway is shown. In the pathway Dsh, Arm and dTCF act positively while Zw3, Axin, APC and dSno act negatively. Based on epistasis data, we propose two possible locations were dSno may be acting (indicated as question marks) within the Wg pathway. The first possibility is that dSno cooperates with the other antagonistic proteins Zw3, dAxin and APC (representing dAPC1 and dAPC2). The second possibility is that dSno blocks Arm activity at a point subsequent to the destruction complex and prevents it from regulating Wg target genes. The embryonic Wg antagonist Brinker does not inhibit Wg functions during wing development.