FIG. 4.
Modulation of AFB-DNA adduct formation in the context of the GSTM1 genotype status. A total of 11 different hepatocyte preparations were examined for AFB-DNA binding in the presence or absence of 10μM SFN pretreatment. Six of the samples were GSTM1 null and five were GSTM1 positive. AFB-DNA adducts per 107 nucleotides were calculated and are shown. Each bar represents the mean and SEM. ANOVA indicated variances that were not statistically different among the groups. Statistical significance was determined by unpaired t-test with equal variances. All groups were significantly different (p < 0.05), with p values for individual comparisons shown.