FIG. 3.

Allethrin does not significantly affect voltage dependency of activation or inactivation of whole-cell VGCC current. Activation curves (A and C) were generated by normalizing the conductance observed at test pulses from −70 to + 20 mV to the maximum conductance. For inactivation curves (B and D), cells were subjected to a 200-ms prepulse at potentials ranging from −70 to 0 mV before testing VGCC current response at 0 mV. The current observed during the test pulse was normalized to the maximum current obtained. No significant effect was observed on the voltage dependency of activation or inactivation during exposure to AL (also see Tables 1 and 2).