FIG. 6.

Allethrin shifts the activation and inactivation of GVIA-insensitive current but does not affect activation or inactivation of NIM-insensitive current. Activation curves (A and C) were generated by normalizing the conductance observed at test pulses from −70 to 20 mV to the maximum conductance. For inactivation curves (B and D) cells were subjected to a 200-ms prepulse of potentials ranging from −70 to 0 mV before testing VGCC current response at 0 mV. Inactivation data were normalized to the maximum current. A clear shift in activation and inactivation is present in GVIA-treated cells exposed to AL (also see Tables 1 and 2). These shifts are likely mediated by L-type VGCCs, as they are absent when cells are treated with the L-type inhibitor, NIM.