TABLE 3.
Allethrin Does Not Significantly Affect Activation, Inactivation, or Deactivation Rate Constants (τ) under Any Condition Tested
| τact (ms) | τinact (ms) | τdeact (ms) | |
| Control | 4.7 ± 0.8 | 82.1 ± 10.3 | 3.1 ± 0.8 |
| 5μM AL | 6.2 ± 0.9 | 114.2 ± 24.9 | 3.1 ± 0.9 |
| TTX | 4.1 ± 1.1 | 114.5 ± 21.1 | 4.3 ± 0.9 |
| TTX + 5μM AL | 4.2 ± 0.5 | 177.4 ± 45.7 | 3.5 ± 1.2 |
| GVIA | 4.3 ± 1.9 | 225.4 ± 78.7 | 2.3 ± 0.6 |
| GVIA + 5μM AL | 4.3 ± 0.8 | 253.8 ± 88.1 | 2.2 ± 0.5 |
| NIM | 4.5 ± 0.7 | 123.1 ± 20.0 | 3.3 ± 1.0 |
| NIM + 5μM AL | 4.7 ± 0.4 | 104.7 ± 19.0 | 2.9 ± 0.8 |
Note. See “Materials and Methods” section for description of estimation of τ. No significant differences were observed in any of the rate constants (ANOVA, p > 0.05), although GVIA treatment resulted in slower τinact, consistent with an increased proportion of L-type current, which inactivates more slowly than other VGCC subtypes. Values are reported as the mean ± SEM, n = 5–7 cells per condition.