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. 2010 May 24;116(2):477–487. doi: 10.1093/toxsci/kfq156

FIG. 7.

FIG. 7.

The NOEC for E2 plus BPA or BPAF. The NOECs are for BPA or BPAF when combined with the stated concentrations of E2 and indicate which concentration of BPA or BPAF is necessary to induce a statistically significant response in the binary mixture. Increasing levels of BPA or BPAF are required to enhance the estrogenicity of the in vitro mixture as the E2 levels increase. Arrows indicate lowest measured E2 levels in humans and prepubertal boys and girls, respectively. T47D-KBluc assay reached saturation and maximal response was induced; hence, NOEC cannot be calculated; n/a, not applicable.