Figure 5.

Plot of mesothelioma copy number alteration profiles based on class membership from recursively partitioned mixture model (RPMM) of DNA methylation data indicates a global correlation between methylation class and extent of copy number alteration. The RPMM was generated with DNA methylation data from 158 tumors as we reported previously; the original RPMM contained seven classes, and the 23 tumors plotted here represent membership in six of the seven classes, where none of the 23 tumors were members of the original RPMM class 5. In the copy number profiles green indicates loss and red indicates gain. The right panel of the figure displays the mean (circle) and standard error (line) of methylation-class-specific percent of SNP loci with altered CN. Grey triangles in the middle portion of the figure indicate which samples have allele loss at DNMT1.