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A) Intracellular signaling events induced by increasing concentrations of NVP-BEZ235 in vitro in the RCC cell lines 786-0 and 769-P. B) Inhibition of cell proliferation by increasing concentrations of NVP-BEZ235 in vitro as determined by MTS Assay. Proliferation is expressed as the percent viable cells in NVP-BEZ235-treated culture compared with that of cells treated with DMSO. Each bar represents the mean of three independent experiments (error bar = 1 S.D.)
