Skip to main content
. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Clin Cancer Res. 2010 Jul 6;16(14):3628–3638. doi: 10.1158/1078-0432.CCR-09-3022

Figure 5.

Figure 5

Antitumor activity of of NVP-BEZ235 compared with rapamycin in 786-O and A498 xenografts. A) Growth curves of 786-O and A498 xenografts in nude beige mice treated with saline, rapamycin, or NVP-BEZ235 daily by gavage. Each treatment group was comprised of 8 mice in 786-O model (6 mice in A498), and each data point represents the mean estimated tumor volume of the tumors (error bar = 1 S.D.). B) Intracellular signaling events in 786-O and A498 xenografts from mice treated with saline (S), rapamycin (R), or NVP-BEZ235 (B) for 3 days.