Table 1:
Simulation study: median computed based on 500 replicates
| True model | Correlation | Assumed model | Positive | True positive | P-value |
|---|---|---|---|---|---|
| Cox | 0.1 | Cox | 27 | 15 | < 0.0001 |
| Additive | 36 | 4 | 0.153 | ||
| AFT | 50 | 5 | 0.306 | ||
| 0.6 | Cox | 18 | 15 | < 0.0001 | |
| Additive | 38 | 8 | < 0.001 | ||
| AFT | 40 | 4 | 0.020 | ||
| Additive | 0.1 | Cox | 40 | 5 | 0.418 |
| Additive | 25 | 13 | 0.023 | ||
| AFT | 10 | 0 | 0.731 | ||
| 0.6 | Cox | 40 | 5 | 0.231 | |
| Additive | 22 | 13 | 0.012 | ||
| AFT | 10 | 0 | 0.402 | ||
| AFT | 0.1 | Cox | 27 | 10 | < 0.0001 |
| Additive | 25 | 8 | 0.006 | ||
| AFT | 26 | 14 | < 0.0001 | ||
| 0.6 | Cox | 17 | 9 | < 0.001 | |
| Additive | 13 | 5 | 0.002 | ||
| AFT | 22 | 15 | < 0.0001 |
Positive: number of genes identified; true positive: number of identified genes truly associated with disease; P-value: P-value of the logrank statistic.