Figure 4.
Baseline activity and motor effects of test drugs in LV-Cre and LV-GFP mice. a, Diazepam effects on locomotor activity. Baseline motor activity (control) was measured by examining the total ambulatory distance (in cm) during the 30 min open field test session. To examine the motor-impairing effects of diazepam, mice were given test drug injection (intraperitoneally) 30 min before open field testing. The motor-impairing effects of diazepam are significantly blunted in mice with decreased α1-GABAARs in the amygdala at the 10 mg/kg dose. b, With zolpidem, motor-impairing effects are significantly blunted at both the 0.25 mg/kg and 0.5 mg/kg dose. Total ambulatory distances are expressed as mean + SEM. Star indicates that the difference between virus groups was statistically significant (p < 0.05).