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The time taken to induce mitochondrial permeability transition pore (mPTP) opening in murine ventricular cardiomyocytes treated with visfatin (100 ng/ml) in the presence or absence of the PI3K and MEK1/2 inhibitors wortman-nin (Wort, 100 nmol/L) and U0126 (10 μmol/L), respectively. Visfatin delays the time taken to induce mPTP opening, an effect that is abolished in the presence of the kinase inhibitors. n > 20 cells per group. *P < 0.01.
