Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2010 Jul 18.

Published in final edited form as: J Mol Biol. 2010 Feb 1;397(2):467–480. doi: 10.1016/j.jmb.2010.01.052

Table 1.

HLA-G^KGPPAALTL contacts

Peptide residue	HLA-G residue	Interaction
Lys1
Lys	Met5, Tyr7, Tyr59, Glu62, Glu63, Tyr159, Trp167, Tyr171	vdW
Lys^N	Tyr7^OH	H-bond
	Tyr171^OH	H-bond
Lys^Nz	(Glu62^Oε2), Glu62^Oε1	Salt bridge
	(Glu63^Oε2, Glu63^Oε1)	Salt bridge
Lys^O	Tyr159^OH	H-bond
Gly2
Gly	Tyr7, Glu63, Tyr159	vdW
Gly^N	Tyr7^OH	H-bond
	Glu63^Oε2	H-bond
Gly^O	Glu63^Oε1	Water-mediated H-bond
	Asn66^Nδ2	Water-mediated H-bond
Pro3
Pro	Asn66, Trp97, Tyr159	vdW
Pro4
Pro	Asn66	vdW
Ala5
Ala	Arg156	vdW
Ala^O	Arg156^NH1	H-bond
	Arg156^NH2	H-bond
Ala6
Ala	His70	vdW
Ala^N	Ala69^O	Water-mediated H-bond
	Thr73^Oγ1	Water-mediated H-bond
Leu7
Leu	Thr73, Asn77, Glu114, Tyr116, Trp133, Arg156	vdW
Leu^N	Trp97^Nε1	Water-mediated H-bond
	Tyr116^OH	Water-mediated H-bond
Leu^O	Asn77^Nδ2	H-bond
Thr8
Thr	Asn77, Lys146	vdW
Leu9
Leu	Asn77, Thr80, Leu81, Tyr84, Tyr123, Leu124, Ser143, Lys146	vdW
Leu^N	Asn77^Oδ1	H-bond
Leu^O	Tyr84^OH	H-bond
	Ser143^Oγ	H-bond
Leu^OXT	Lys146^Nζ	H-bond
	Asn77^Oδ1	Water-mediated H-bond
	Thr80^Oγ1	Water-mediated H-bond