Skip to main content
. Author manuscript; available in PMC: 2010 Jul 18.
Published in final edited form as: J Am Chem Soc. 2008 Jun 24;130(28):9025–9030. doi: 10.1021/ja800948c

Figure 5.

Figure 5

PIP2 isomer specificity of subphase NaCl expansion effect. (A) Area per molecule at π = 30 mN/m of DO- PIP2 isomers on HEPES-buffered subphase. Mean ± SE, n=7. (B) Difference in area per molecule of DO- PIP2 isomers between 250 mM NaCl and no subphase NaCl. The isomer dependence of the NaCl effect was measured to be significant to p = 0.0001 by two-way ANOVA. (C) Conceptual cartoon of the intermolecular interactions between PIP2 molecules. In absence of chaotropic agents (green ellipses), PIP2 molecules form water-mediated hydrogen-bonded networks. Upon addition of chaotropes, networks are broken, and electrostatic repulsion between charged phosphates induces expansion of the monolayer.