Figure 1.
Reaction of tyrosinate anion with chlorpyrifos oxon to yield diethoxyphosphorylated tyrosine. The anion of tyrosine is stabilized by interaction with positively charged arginine and lysine side chains. The tyrosine anion reacts with chlorpyrifos oxon to make a covalent bond with diethoxyphosphate while displacing 3,5,6-trichloro-2-pyridinol.