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. Author manuscript; available in PMC: 2010 Jul 19.
Published in final edited form as: Curr Opin Investig Drugs. 2008 Jun;9(6):576–582.

Figure 1. The Notch1 signaling pathway.

Figure 1

Notch1 is a transmembrane receptor that is activated by proteolytic cleavage following ligand binding. The Notch1 intracellular domain (NICD) translocates into the nucleus where it forms a complex with CBF1 and other proteins to activate gene transcription.