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. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: Pharmacogenet Genomics. 2010 Jan;20(1):26–37. doi: 10.1097/FPC.0b013e3283343296

Fig 5 — Enzyme efficiency (V_max/K_m) for SMX-HA reduction from kinetic determinations in a subset of 18 WT human livers, compared to data obtained from livers with CYB5A or CYB5R3 cSNPs. Reduction activities for human livers in the subset were in three defined ranges (>90^th percentile, n=7; 45^th–55^th percentile, n=6; <10^th percentile, n=5). *R59H and *R297H denote separate calculated efficiencies for the high affinity components observed in these heterozygous livers. Individual apparent K_m and V_max values are given in the text.