. Author manuscript; available in PMC: 2010 Jul 19.

Published in final edited form as: Am J Cardiol. 2009 Jan 24;103(6):755–761. doi: 10.1016/j.amjcard.2008.11.035

Table 4.

Hazard ratios and 95% confidence intervals per 1 standard deviation increase in baseline value of predictor for incident Coronary Heart Disease morbidity or mortality comparing a model with (Center for Epidemiological Studies- Depression), adjusted for age, sex, and Framingham risk score (model A) to a model additionally including inflammatory markers (model B)

	N	Model A		Model B			Depression Parameter Estimate Difference
		Center for Epidemiological Studies- Depression scale	Center for Epidemiological Studies- Depression scale	Log High sensitivity C-reactive protein	Soluble Intracellular Adhesion molecule-1	Log Interleukin -6
1.	1790	1.27 (1.10–1.47)	1.26 (1.09–1.45)	1.25 (1.02–1.53)			5.68%
2.	1792	1.28 (1.11–1.48)	1.28 (1.11–1.48)		1.32 (1.04–1.66)		−0.08%
3.	1751	1.28 (1.10–1.48)	1.27(1.10–1.47)			1.05 (0.88–1.25)^°	1.22%
4.	1788	1.28 (1.11–1.48)	1.26 (1.09–1.46)	1.24 (1.01–1.52)	1.29 (1.02–1.63)		5.62%
4b. Center for Epidemiological Studies- Depression ≥ 10	1788	1.60 (1.12–2.27)	1.59 (1.12–2.26)	1.26 (1.03–1.54)	1.29 (1.03–1.63)		0.88%
5. Men	890	1.25 (1.02–1.52)	1.22 (1.00–1.50)	1.23 (0.94–1.61)^°	1.10 (0.80–1.51)^°		8.45%
6. Current smokers	475	1.49 (1.21–1.83)	1.55 (1.25–1.92)	1.00 (0.68–1.46)^°	1.58 (1.04–2.40)		−10.77%
7. Age ≥65 years	345	1.23 (0.94–1.61)^°	1.20 (0.92–1.58)^°	1.23 (0.90–1.66)^°	1.70 (1.17–2.48)		11.10%
8. Body Mass Index ≥30	404	1.46 (1.15–1.86)	1.48 (1.16–1.89)	0.95 (0.66–1.36)^°	1.17 (0.71–1.92)^°		−3.70%
9. Not prescribed cardiac^** medications	1563	1.19 (0.99–1.43)^°	1.16 (0.97–1.40)^°	1.33 (1.04–1.70)	1.28 (0.97–1.67)^°		12.38%
10. Not prescribed anti- depressant medication	1736	1.24 (1.06–1.46)	1.22 (1.04–1.43)	1.23 (1.00–1.53)	1.29 (1.01–1.64)		−8.89%

^°

not significant

^**

aspirin, lipid-lowering medications and anti-hyerpertensive medications

1 standard deviation of depressive symptoms = 7.7 points;

1 standard deviation of log(high sensitivity C-reactive protein) = 1.25; 1 standard deviation of soluble intracellular adhesion molecule-1 = 330 ng/mL; 1 standard deviation of log(interleukin-6) = 0.79