Figure 3.
CTZ does not change PPR through saturation. The change in EPSC amplitude and PPR upon addition of CTZ was quantified for individual cells. Some cells showed large changes in PPR, whereas others showed less effect. The amplitude of EPSC1 (open symbols) changed uniformly regardless of the effect on PPR, while the amplitude of EPSC2 (closed symbols) correlated with effect on PPR. These results are not consistent with CTZ reducing depression by increasing saturation of the first pulse (see Results for explanation). These results are pooled from experiments conducted in 1.5 Cae (triangles) and 3 Cae (circles). Lines are fits to the data.