Figure 1 ¹¹C-PiB imaging for HIV+ participants and community controls

Representative structural MRI and amyloid binding agent N-methyl-[¹¹C]2-(4-methylaminophenyl)-6-hydroxybenzothiazole (¹¹C-PiB) image from (A) an unimpaired HIV-infected (HIV+) participant with low CSF amyloid-β42 (Αβ42) (<500 pg/mL) and (B) an unimpaired community control with low CSF Αβ42 (<500 pg/mL). On visual inspection, greater binding potentials were seen for the community control compared to the HIV+ subject. The community control had values similar to a participant with Alzheimer dementia (AD) and may have preclinical disease.