Table 1.
Body weight, lipid profile and blood pressure in the control and diabetic ZDF rats at the initial and final time (6 weeks of vehicle or sitagliptin treatment).
| Initial Time (20 wks) | Final Time (26 wks) | ||||
|---|---|---|---|---|---|
|
| |||||
| Control ZDF (+/+) | Diabetic ZDF (fa/fa) | Control ZDF (+/+) | Diabetic ZDF (fa/fa) | ||
|
| |||||
| Groups | (n = 16) | (n = 16) | Vehicle (n = 8) | Vehicle (n = 8) | Sitagliptin (n = 8) |
| BW (g) | 406.70 ± 6.83 | 388.10 ± 8.87 | 445.70 ± 8.16 | 354.40 ± 8.85aaa | 380.00±14.46 |
| Total-c (mg/dl) | 77.50 ± 1.50 | 155.50 ± 3.50aaa | 93.00 ± 2.96 | 193.00 ± 9.79aaa | 193.10±4.62 |
| TGs (mg/dl) | 115.00 ± 11.00 | 374.50 ± 4.95a | 154.00 ± 19.14 | 400.20 ± 27.00aaa | 237.10 ± 22.54bbb |
| Systolic (mmHg) | 115.50 ± 0.83 | 125.20 ± 0.27 | 116.00 ± 2.52 | 127.80 ± 1.23a | 101.60 ± 0.78bbb |
| Diastolic (mmHg) | 100.98 ± 0.82 | 91.46 ± 0.83 | 103.50 ± 1.94 | 112.70 ± 3.98 | 94.86 ± 0.70bbb |
| Mean (mmHg) | 104.25 ± 0.25 | 108.20 ± 1.42 | 104.30 ± 4.25 | 117.40 ± 3.04a | 96.86 ± 0.51bbb |
| Pulse P (mmHg) | 14.52 ± 0.98 | 33.74 ± 0.37 | 14.00 ± 4.16 | 15.09 ± 3.08 | 6.71 ± 1.11b |
BW, body weight; P, pressure; SITA, sitagliptin; Total-c, Total-cholesterol; TGs, triglycerides; ZDF, Zucker diabetic fatty. Values are means ± SEM of n rats. Comparisons between groups: a - ZDF (fa/fa) versus ZDF (+/+) and b - sitagliptin versus vehicle; P < .05, P < .01 and P < .001 for one, two or three letters, respectively.