Table 1.
Metabolite levels measured by 1H MRS in 786-0 tumor extracts.
| Metabolite | EV | HIF-1+ | HIF-2+ |
|---|---|---|---|
| Leucine | 0.13 ± 0.01 | 0.17 ± 0.02 | 0.17 ± 0.01a |
| Iso Leucine | 0.06 ± 0.01 | 0.08 ± 0.005 | 0.08 ± 0.005a |
| Lactate | 5.13 ± 0.85 | 5.43 ± 0.51 | 2.54 ± 0.58a,b |
| Alanine | 0.84 ± 0.06 | 0.88 ± 0.05 | 0.63 ± 0.04a,b |
| Choline | 0.17 ± 0.02 | 0.22 ± 0.04 | 0.29 ± 0.05a |
| PC | 0.73 ± 0.09 | 0.66 ± 0.14 | 1.14 ± 0.05a,b |
| Taurine | 13.96 ± 1.55 | 13.02 ± 0.92 | 16.70 ± 0.66b |
| Cr | 1.26 ± 0.14 | 1.46 ± 0.15 | 2.00 ± 0.17a,b |
| Glucose | 0.63 ± 0.10 | 0.73 ± 0.12 | 1.19 ± 0.29a |
| ATP+ADP | 0.91 ± 0.20 | 0.95 ± 0.13 | 1.14 ± 0.15 |
Metabolites expressed as μmol/g wet weight tissue (n = 3–5). adenotes statistically significant different from EV and bdenotes statistically significant difference (P < .05) from HIF-1+. A two-tailed t test was used for significance levels.