Figure 4.

Store-operated Ca²⁺ entry in 3xTg and PS DKO hippocampal neurons. A, B, Fura-2 340 nm/380 nm ratio traces are shown for PScDKO hippocampal neurons infected with Lenti-GFP or Lenti-Cre viruses (A) and WT or 3xTg hippocampal neurons (B). The neurons were moved from aCSF to Ca²⁺-free media for 120 s and then returned to aCSF. Individual cell traces (gray) and average traces (red) are shown for each group of neurons. C, An average fura-2 peak responses to Ca²⁺ readdition are shown for PScDKO neurons infected with Lent-GFP or Lenti-Cre and for WT or 3xTg neurons. The average peak SOC responses are shown as mean ± SE (n indicates number of cells analyzed in each group). **p < 0.01; ***p < 0.001.