Figure 8.

Long-term dantrolene feeding increases amyloid accumulation in brains of APPPS1 mice. A, The coronal sections from dantrolene-fed (Dan) or vehicle-fed (Veh) APPPS1 mice were stained with anti-Aβ monoclonal antibody and fluorescently labeled secondary IgG. Representative fluorescent images of coronal slices from vehicle-fed and dantrolene-fed APPPS1 mice are shown. B, Quantification of average plaque size, pixel intensity, and plaque number in forebrain sections of dantrolene-fed and vehicle-fed APPPS1 mice. a.u., Arbitrary units. The data for each group are shown as mean ± SE (n = 6 mice). ***p < 0.001.