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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Pediatr Res. 2010 May;67(5):532–537. doi: 10.1203/PDR.0b013e3181d4ff4d

Figure 1. Phenobarbital + delayed hypothermia attenuates early forepaw placing deficit.

Figure 1

Postnatal-day-7 (P7) rats (n=68) underwent unilateral cerebral hypoxia-ischemia and then received i.p. injections of phenobarbital 40 mg/kg or an equivalent volume of saline, recovered in a 37°C incubator for 1h (n=32) or 3h (n=36), then were cooled for 3h (30°C incubator). Lateral vibrissae-stimulated forepaw placing (10 trials/side) was evaluated on P14. Saline+delayed hypothermia (dHT)-treated animals had contralateral placing deficits; this deficit was attenuated in the group treated with phenobarbital prior to delayed HT (PB+dHT). Results were the same whether the delay to initiation of HT was 3h or 1h (*p<0.005 and †p<0.05, Mann-Whitney, vs. corresponding saline+dHT controls).