Table 2.
Phenobarbital plus delayed hypothermia attenuates hypoxic-ischemic damage: Early outcome regional brain volumes
| Cortex | Striatum | Hippocampus | |||||
|---|---|---|---|---|---|---|---|
| n | Left | Right | Left | Right | Left | Right | |
| SAL+1h dHT | 16 | 62 ± 10 | 27 ± 25 | 23 ± 2 | 14 ± 7 | 9 ± 4 | 5 ± 5 |
| PB+1h dHT * | 16 | 65 ± 12 | 42 ± 26 † | 22 ± 4 | 17 ± 7 | 10 ± 4 | 6 ± 5 |
| SAL+3h dHT | 17 | 68 ± 12 | 37 ± 25 | 23 ± 2 | 14 ± 7 | 10 ± 4 | 6 ± 4 |
| PB+3h dHT * | 17 | 67 ± 12 | 50 ± 24 † | 22 ± 4 | 17 ± 8 | 10 ± 4 | 8 ± 6 |
| Total | |||||||
| SAL+dHT | 33 | 64 ± 11 | 32 ± 25 | 23 ± 3 | 14 ± 7 | 10 ± 4 | 5 ± 5 |
| PB+dHT * | 33 | 66 ± 12 | 46 ± 25 † | 23 ± 3 | 17 ± 7 | 10 ± 4 | 7 ± 5 |
Values represent left- and right-hemisphere volumes (mm3, mean±SD).
*
p<0.05 Main effect of phenobarbital treatment by 3-way ANOVA, factoring treatment, regional volume and delay. By post-hoc tests, delay to initiation of cooling (1 h vs. 3 h) did not affect outcome.
†
Fisher PLSD post-hoc tests (p<0.05).