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. Author manuscript; available in PMC: 2010 Jul 19.
Published in final edited form as: Sci Signal. 2009 Jan 27;2(55):ra2. doi: 10.1126/scisignal.2000189

Figure 3. mTor inactivation opposes Pten-loss induced tumor progression from in situ to invasive cancer lesions.

Figure 3

(A) MRI analysis of prostatic tumors (dashed yellow circles) in Ptenpc−/− and Ptenpc−/−;mTorpc−/− 6 month old mice. (B) H&E staining of AP sections from 6 month old Ptenpc−/− and Ptenpc−/−;mTorpc−/− mice. Focal invasion in Ptenpc−/− mouse prostate is indicated by an arrow. Inflammatory infiltration in Ptenpc−/− mouse prostate is shown at higher magnification in the lower left panel. Lower right panel: percentage of Ptenpc−/− and Ptenpc−/−;mTorpc−/− 6 month old mice with signs of invasion in the prostate. Four mice from each genotyping were analyzed. **, P < 0.01.