α values, number of iterations, and temperature RMSE for all parameter sets. For the ex vivo porcine tissue case, the ex vivo training data sets were used to determine the α value and number of iterations. For the in vivo canine case, 2 sets of reconstructions were performed: one in which the in vivo training data was used to determine the α and iteration values (top rows) and one where the α and iteration values were taken from the ex vivo case (bottom rows). Only the validation data sets were used to determine the temperature RMSE.