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. Author manuscript; available in PMC: 2010 Jul 19.
Published in final edited form as: Nano Lett. 2008 Aug 30;8(10):3418–3422. doi: 10.1021/nl802218f

Figure 2.

Figure 2

Dwell-time distributions for three DNA samples through 2 nm pores. a) a ssDNA molecule consisting of 120-mer poly-deoxyadenine molecule. b) blunt dsDNA, consisting of a 24-bp duplex region and a 6-base loop. c) a hybrid single-strand/duplex molecule, consisting of a 100-mer strand hybridized to a fully-complementary 50-mer at one end. While the dwell-times for ssDNA and blunt dsDNA are short (< 21 μs), noticeably longer dwell-times are observed for the hybrid molecule. The complete dwell-time distribution for the hybrid molecule can be modeled as a bi-exponential function with decay timescales t0 = 40 μs and t1 = 240 μs, corresponding to a collision and translocation/unzipping process, respectively. Typical events for the three samples are shown as insets to the dwell-time distributions.