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. Author manuscript; available in PMC: 2011 May 7.
Published in final edited form as: J Org Chem. 2010 May 7;75(9):2820–2835. doi: 10.1021/jo1000109

Figure 3.

Figure 3

Competitive Binding Assay for Reblastatin (1) and Structural Analogs 6, 37–38 to Hsp90 obtained from MDA-MB-468 Breast Cancer Cell Lysate. Reblastatin (1) binds to Hsp90 with slightly better nanomolar activity (7.34 nM) than geldanamycin (3, 34–42 nM). Derivative 6 also showed good inhibitory activity (70.3 nM). Compounds 37 and 38 were inactive in the binding assay.