. Author manuscript; available in PMC: 2011 May 7.

Published in final edited form as: J Org Chem. 2010 May 7;75(9):2820–2835. doi: 10.1021/jo1000109

Table 1.

Cytotoxicity and Hsp90 Binding Affinity of Reblastatin (1), Autolytimycin (2), 17-AAG (4) and Analogs (7–9).

Compound	Hsp90 K_d (nM)^a	Kasumi-1 IC₅₀ (nM)^b	MOLM-13 IC₅₀ (nM)^b
reblastatin (1)	26	290	270
autolytimcyin (2)	36	280	510
7	84	760	1550
8	1475	7280	5930
9	1265	9030	9590
17-AAG (4)^c	110	480	90

Competitive binding to Hsp90α, see SI for experimental details

See SI for experimental details

Internal standard