Skip to main content
. Author manuscript; available in PMC: 2010 Jul 19.
Published in final edited form as: Circulation. 2004 Sep 27;110(14):2060–2065. doi: 10.1161/01.CIR.0000143627.55926.4C

Figure 2.

Figure 2

Bar graph and representative cross sections of infrarenal aortas comparing intima-media ratios of rabbits receiving 0.5 mg/kg candesartan daily with placebo control. Intima-media ratio of infrarenal aortas was 1.57±0.08 (mean±SEM) for placebo group compared with 1.18±0.08 for candesartan-treated animals (P<0.001). Intra-aortic thrombi developed in 11 of 15 rabbits in control group compared with 3 of 13 in candesartan-treated group (P<0.05). Representative histological sections of rabbit aortas after triggering but before euthanization in (A) candesartan group (0.5 mg/kg) showed little intimal thickening with no thrombus seen and in (B) placebo control rabbits, showing significant intimal thickening and thrombus.