FIGURE 3.

Interactions between viral proteins that occur during virion assembly. Black arrows indicate genetic interactions between viral components that have been identified by passaging viral genomes, which are defective in one gene (e.g. core), until compensatory mutations arise within other coding regions that restore the generation of infectious progeny (e.g. p7). Red arrows show core-NS5A, core-E1, and E1-E2 interactions that have been determined experimentally. The blue arrow indicates colocalization between NS2 and E2, but there is no available evidence for physical association between the proteins.