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A, H2O2 (500 μm) activates IClswell directly in both WT and ClC-3 null cells. Typical current records (above) are paired with I/V plots of peak currents (below). B, scavenging of H2O2 with catalase (1000 units/ml) inhibits IClswell activation by TNF-α. Error bars, S.E.
