FIGURE 8.
Effect of APC(S360A) on intrinsic thrombin generation in normal plasma and in FVLeiden plasma. Thrombin generation was measured by CAT as described under “Experimental Procedures” in normal plasma (A) or a plasma pool from three donors carrying the R506Q mutation (B) triggered via the intrinsic pathway in the presence of varying concentrations of wt-APC (●) or APC(S360A) (○). Averaged endogenous thrombin potential (ETP) values from three titrations are shown with standard errors of the mean/point not exceeding 15% of the measurement.