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. 2010 May 24;285(30):23165–23176. doi: 10.1074/jbc.M109.084046

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Model of SYT1 delivery to the plasma membrane. SYT1 is synthesized on ER and delivered to PM through the exocytotic pathway. The default pathway of SYT1 is thought to be Golgi or TGN. Two tandem calcium-binding domains function as a determinant of PM localization and also the prevention of up-taking SYT1 to the endocytotic pathway. PM, plasma membrane; Golgi, Golgi apparatus; TGN, trans-Golgi network; ER, endoplasmic reticulum; EE, early endosome; LE, late endosome; MVB, multivesicular body.