Skip to main content
. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Epilepsia. 2009 Oct 20;51(3):371–383. doi: 10.1111/j.1528-1167.2009.02339.x

Figure 5.

Figure 5

Timeline for seizure and spike progression for rats with CSE (convulsive status epilepticus). Times given in the figure represent ranges for the duration of each interval. Both seizures and spikes were recorded during CSE, after which EEG spikes decreased in frequency (top timeline). In all rats with CSE (n=9), spike clusters occurred prior to the end of the seizure-free interval. Spike clusters, once present, persisted for the life of the animal. Convulsive seizures appeared during kainate treatment for rats with CSE, and resolved within 24 h (bottom timeline). Spontaneous seizures occurred after a seizure-free interval, with seizure frequency increasing continuously from a low initial frequency to a high-frequency plateau (Williams et al. 2009). The transition phase was defined as the time from the first kainate treatment until 10 seizures were observed per day for 2 consecutive days. This parameter was used to assess possible correlations between spiking and epileptogenesis.