Table 2.
Genotype and allele frequencies of NOS2 polymorphisms Ser608Leu, -954G/C and -1173C/T in gastric adenocarcinoma (GA), chronic gastritis (CG), and control (C) groups.
| Genotypes/Alleles | GA N = 150 (%) |
C N = 164 (%) |
OR (95%CI) | p | CG N = 160 (%) |
C N = 164 (%) |
OR (95%CI) | p |
|---|---|---|---|---|---|---|---|---|
| Ser608Leu | ||||||||
| CC | 106 (70.7) | 113 (69) | 0.92 (0.57-1.49) | 0.81 | 107 (66.9) | 113 (69) | 1.10 (0.69-1.75) | 0.72 |
| CT | 36 (24) | 39 (23.8) | 33 (20.6) | 39 (23.8) | ||||
| TT | 8 (5.3) | 12 (7.2) | 20 (12.5) | 12 (7.2) | ||||
| Alleles | ||||||||
| C | 0.83 | 0.81 | 0.88 (0.59-1.32) | 0.61 | 0.77 | 0.81 | 1.24 (0.85-1.82) | 0.29 |
| T | 0.17 | 0.19 | 0.33 | 0.19 | ||||
| -954G/C | ||||||||
| GG | 77 (51.3) | 115 (70.1) | 2.23 (1.4-3.53) | <0.01 | 115 (71.9) | 115 (70.1) | 0.92 (0.57-1.49) | 0.81 |
| GC | 62 (41.3) | 38 (23.2) | 36 (22.5) | 38 (23.2) | ||||
| CC | 11 (7.4) | 11 (6.7) | 9 (5.6) | 11 (6.7) | ||||
| Alleles | ||||||||
| G | 0.72 | 0.82 | 1.74 (1.19-2.53) | <0.01 | 0.83 | 0.82 | 0.91 (0.6-1.36) | 0.68 |
| C | 0.28 | 0.18 | 0.17 | 0.18 | ||||
| -1173C/T | ||||||||
| CC | 150 (100) | 164 (100) | ND | ND | 160 (100) | 164 | ND | ND |
| CT | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||||
| TT | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||||
| Alleles | ||||||||
| C | 1 | 1 | ND | ND | 1 | 1 | ND | ND |
| T | 0 | 0 | 0 | 0 |
N, Number of individuals; OR, Odds Ratio; CI, Confidence Interval; P, probability; ND, not done.