Table 3.
Distribution of risk factors, genotypes of NOS2 polymorphisms Ser608Leu and -954G/C, and odds ratios (OR) for gastric adenocarcinoma (GA), chronic gastritis (CG), and control (C) groups.
| Variables | GA × C | CG × C | ||||
|---|---|---|---|---|---|---|
|
GA/C N |
OR (95%CI) | p |
CG/C N |
OR (95%CI) | p | |
| Gender | ||||||
| Female | 36/78 | Reference | 82/78 | Reference | ||
| Male | 114/86 | 1.79 (1.02-3.15) | 0.04 | 78/86 | 0.52 (0.31-0.88) | 0.01 |
| Age | ||||||
| <57 years | 42/96 | Reference | 91/96 | Reference | ||
| ≥57 years | 108/68 | 2.94 (1.77-4.90) | <0.01 | 69/68 | 1.03 (0.64-1.65) | 0.88 |
| Smoking | ||||||
| Nonsmokers | 43/103 | Reference | 73/103 | Reference | ||
| Smokers | 107/61 | 2.68 (1.58-4.53) | <0.01 | 87/61 | 1.93 (1.19-3.13) | <0.01 |
| Alcohol | ||||||
| Nondrinkers | 65/132 | Reference | 100/132 | Reference | ||
| Drinkers | 85/32 | 3.60 (2.05-6.32) | <0.01 | 60/32 | 2.79 (1.55-5.02) | <0.01 |
| Ser608Leu | ||||||
| CC | 106/111 | Reference | 108/111 | Reference | ||
| CT+TT | 44/53 | 1.19 (0.69-2.08) | 0.51 | 52/53 | 1.12 (0.68-1.83) | 0.64 |
| -954G/C | ||||||
| GG | 77/112 | Reference | 116/112 | Reference | ||
| GC+CC | 73/52 | 1.87 (1.12-3.13) | 0.01 | 44/52 | 0.83 (0.50-1.38) | 0.48 |
N, Number of individuals; OR, Odds Ratio; CI, Confidence Interval; P, probability.