Table 2.

Mean derived pharmacokinetic profiles for ibuprofen and paracetamol after administration of the fixed-dose combination tables in the fed and fasted states (Study 1)

	Ibuprofen		Paracetamol
	Fed	Fasted	Fed	Fasted
n	25	25	25	25
tmax, hrs	2.00a	1.25a	1.50a	0.50a
Median difference [minutes] fed vs fasted, 95% CI	25.0, 0.0-45.0		55.0, 30.0-80.0
t1/2, hrs	2.25	1.95	2.73	2.83
Cmax, μg.mL-1	24.74	32.04	11.14	18.48
LS geometric mean	24.03	31.46	10.71	17.58
Ratio fed/fasted (%), 90% CI	76.38, 70.25-83.06		60.92, 53.43-69.46
AUC0-t, μg.mL-1.hr	103.91	118.32	46.45	51.69
LS geometric mean	101.6 2	116.51	45.69	50.27
Ratio fed/fasted (%), 90% CI	87.22, 84.06-90.49		90.89, 87.38-94.54
AUC0-inf, μg.mL-1.hr	109.03	120.92	49.51	54.49
LS geometric mean	106.04	118.82	48.72	52.95
Ratio fed/fasted (%), 90% CI	89.25, 86.14-92.46		92.01, 88.45-95.71
Kel	0.328	0.361	0.258	0.251

AUC_0-inf: area under the curve calculated by linear trapezoidal rule to the last measurable plasma concentration (Cp) with additional area calculated from Cp/Kel; AUC_0-t: area under the curve calculated by linear trapexoidal rule to the last measurable plasma concentration; C_max: maximum plasma concentration; Kel: elimination rate constant; t_max: time of maximum plasma concentration; hr(s): hour(s); LS: least square; sd: standard deviation. ^aMedian values.